Old Crow Medicine Show is a string band based in Nashville, TN. They started in 1998 by busking on street corners from New York state through northeast Canada. In 2000, they traveled to Boone, NC, hoping to catch the attention of the legendary Doc Watson, and they did, while playing in front of the same pharmacy he did many years earlier. He invited them band to play at his MerleFest Music Festival, and that launched their career.

The group’s music is considered old-time folk because many of the songs they perform are pre-WW2 blues and folk songs, but done with punk rock energy. Their sound influenced Mumford & Sons and contributed to a revival of banjo-picking string bands that play Americana music.

Their self-titled album contained “Wagon Wheel” which front man Ketch Secor wrote, basing it on a song fragment he heard on a Bob Dylan bootleg. Dylan was so impressed with that, he sent Secor a partial song called “Sweet Amarillo,” which Secor also expanded and appeared on OCMS' Remedy album, which won a Grammy for Best Folk Album of 2015 .