Starting his career in the late 1970s, Mirwais became known in the French dance music scene for being a member of new wave group Taxi Girl.

After relative obscurity in other locations, he became more widely known when he met and began collaborating with Madonna, the highly successful, internationally-famous American singer; Mirwais and Madonna have collaborated on four of the latter’s albums as of 2019: Music, American Life, Confessions on a Dance Floor, and Madame X.

Regarding his solo work, he is perhaps best known for the song “Disco Science”, which appeared on the soundtrack album of “Snatch”, a film directed by Guy Ritchie, who was, at the time the soundtrack was released, Madonna’s husband.