Method Man of the Wu-Tang Clan and Redman of the Def Squad combined forces while they were both on the Def Jam roster in 1994. Their first collaboration was on the Gold single “How High” from The Show soundtrack. They also collaborated on 2Pac’s “Got My Mind Made Up” in 1996 along with Tha Dogg Pound before Red & Mef began appearing on each other’s albums. They also made appearances together on a number of other tracks such as LL Cool J’s “4, 3, 2, 1” (1997) along with DMX, EPMD’s “Symphony 2000” and D'Angelo’s “Left & Right” among others.

Their first joint album, Blackout!, was released in 1999 and featured the hit single “Da Rockwilder.” They released their follow-up album Blackout! 2 ten years later in 2009. They starred in the movie How High in 2001 and their own short-lived FOX sitcom Method & Red in 2004.